Borrelia burgdorferi - insidious spirochete 2/4 Immunological studies
The primary way to identify infection is to study the presence of przeciwkrętkowych antibodies in the blood. Antibodies Lyme disease appear in the blood until several weeks after illness, so it makes no sense to do the test immediately after tick bite. Wait about 4 weeks.
In late-stage disease antibody tests detect only ONLY about 1 / 3 CASES.
It is associated with a number of reasons: 1: There are many varieties of the Lyme spirochetes and subtypes and All are detected by tests. 2: Testing of different companies can detect only certain subtypes spirochete. May therefore be necessary to repeat tests in different laboratories. 3: In the late stage, probably active spirochetes disappear from the blood and There are only a form or forms of intracellular bezścienne. Not is then possible to activate the immune cells by spirochetes and antibody levels decline. 4: In addition, recently discovered that the spirochete can produce in its Special cell wall protein - a glycoprotein that binds antibody host. Therefore, it is possible that these antibodies are hidden in the protein and methods of detection of these antibodies fail. As a result, despite the duration of infection, the result may appear negative test.
On the other hand, some healthy people may have antibodies against the developed stroke and spontaneous cure, and therefore the value Diagnostic testing antibody level is significantly reduced. In recent cases, the first result of a questionable or positive, it is advisable, therefore, to repeat the results after 4 weeks to determine growth in the amount of antibodies (in the same laboratory).
At negative test results and significant disease is suspected it is recommended in to the extent possible, repeat the test in another laboratory, where it is used a different method for the determination of antibodies. Increases in this way the chance of obtaining a positive result. This However, some patients still remain undiagnosed.
There are other methods for detection of Lyme disease. Sa is a test Westernblot and test DNA. Both are focused increasingly on detection of the spirochete, and not antibodies against it. So give much more positive than the standard tests for preciwciała. Given the cost - about 200-300 zł, it would seem that They should do as a last resort. However, given the fact that tests for antibodies or cost from 1960 to 1990 zł and often need to be repeat, it is to consider doing the test immediately Westernblot or DNA.
There is one method to detect Lyme disease - test biorezonansowy.
There is a method recognized by the medical circles, however, From my humble experience osobistycjh the pursuit of this test for their patients - I can tell, this test is the most sensitive (*). I've had in my practice, patients who had clinically symptoms indicative of possible Lyme disease who have negative results meli tests for antibodies (some also test negative Westernblot), and biorezonansowy test had Lyme disease. Was it really Lyme disease? this question on the 100% no answer.
{-(*)- Sensitivity is the percentage of false negative, specificity - Is the percentage of false positives}
Developmental forms spirochete
Recent studies have shown that the spirochete can exist in three various forms of development, and not one as yet thought. These are: adult form, so called. L and the cyst form. During the These three forms of infection can be passed from one to another, which seems be the cause of previous treatment failures. There are also evidence that the spirochete can produce spores inside cells such as macrophages, lymphocytes, endothelial cells and may thereby avoid the action of antibiotics.
The form of L does not have a cell wall, is so insensitive to many antibiotics used in Lyme disease, acting on the wall cell. Cysts, however, are resistant to almost all antibiotics.
On the basis of knowledge and experience of prof. Enderlein on drobnouswtrojów developmental forms inhabiting in the blood can be expressed However, the hypothesis that the developmental forms borelii may be more ...
tbc ...
MD Piotr Krzysztof Michalak ---- To receive the Newsletter, please visit www.drMichalak.pl and Enter your email address. --- If you believe that someone of your friends would add to the information from this Bulletin - send it to him now that e-mails ... --- I note that the newsletter contains the most knowledge not recognized of academic medicine. ---
