1. Insulin and its effect on human body
Insulin is a peptide hormone produced by the pancreas. The main stimulus for insulin production is increased post-prandial blood glucose. The effect of insulin is to transport glucose into cells, which lowers the concentration of sugar in the blood. Further increases in blood glucose is the body's signal that he is more than you currently need. Then the excess sugar is stored in the form of liver and muscle glycogen. Once is enough supply of glycogen, the sugar is then stored in the form of fat in adipose tissue.
Insulin is an anabolic (synthesis) of intensifying the process of producing glycogen, proteins and fats. Counteracts the catabolic reactions (decay) and improves the use and burning of glucose in muscle cells. Apart from the role in the regulation of glucose metabolism, insulin is also an activator of the process of lipogenesis (fatty acid synthesis), reduces lipolysis (breakdown of fat). It also promotes transport of amino acids (components of proteins) and promotes their accumulation in the cells of skeletal muscle. Enhances the synthesis of mRNA molecules - for the production of matrix proteins specific for each organism, both perfectly interacts with the growth hormone boosting its performance. When there is a deficiency of insulin to inhibit protein synthesis and breakdown, with the release of amino acids into the blood, which then are used to obtain energy from them.
2. Food
The reason why we eat is to attract organic compounds used to produce energy for all metabolic processes and used for reclamation of used tissues. The basic ingredients are consumed carbohydrates, proteins and fats, vitamins and minerals. Eating carbohydrates is not absolutely necessary, because the body can produce energy by burning fat, protein, in special cases. Fat is the body best and most desirable fuel because its consumption does not cause congestion in the excretion of pancreatic insulin. Consuming carbohydrate products and increases the concentration of glucose in the blood, resulting in rapid discharge of insulin from the pancreas into the blood. The appearance of too much sugar in the blood is a shock to all body cells, because our bodies are not evolutionarily adapted to this situation. The consequence of the expulsion of a large excess of insulin into the blood is to produce the opposite phenomenon - too great a drop in blood sugar levels and the emergence of symptoms of hypoglycemia. Appear tremor, sweating, heart palpitations, and increased nervousness - fuses so the appetite for carbohydrates. There is a constant swing in blood sugar levels. In our ancestors ate meat and plants there was no need for increasing amounts of glucose in the blood.
3. Insulin receptors
On the surface of a single cell is about 20 000 seats by which insulin can penetrate into the intracellular space and these are called. insulin receptors. The largest number is located on the membranes of muscle and fat cells. As a result of a combination of insulin with the appropriate membrane receptor, followed by creating a special complex of "insulin-receptor", which allows insulin to penetrate into cells. Receptors are continuously produced in the body, because the insulin molecule can always easily find the right place anchors. Zdarzaa But sometimes, when the quantity is insufficient raceptorów membrane. This is usually the result when the number of molecules of insulin in the blood rises too sharply, and this phenomenon is called hyperinsulinemia.
4. Membrane resistance to insulin
The more the cell membranes and tissues of the internal organs are bombarded with an excess of insulin, including the passage of time increases the resistance of these membranes to the effects of the hormone. As a result, insulin and glucose can not penetrate into the cell. Increases in connection with the concentration of glucose (sugar) and insulin in the blood.
There is an almost direct correlation between high cholesterol and high levels of insulin. Cholesterol has several factions, and the low molecular weight LDL plays the biggest role in atherosclerotic plaque formation. The easiest way to react with oxygen - oxidizes and squeezes through small spaces in the endothelium of blood vessels. His level is constantly raised by the increase in blood insulin levels, and this in turn is the result of cell resistance to excessive levels of this hormone. The cells acquire resistance to insulin because they are trying to protect against the harmful effects of high concentration. Membrane receptors that regulate its activity, would not have to continually receive these harmful stimuli. The longer cells are exposed to excess insulin, that are becoming increasingly resistant to its effects. Paradoxical situation arises when we have a large excess of blood glucose and the cells are hungry and malnourished because cell membranes can not pass up the inside of your blood glucose. It is a stimulus for the pancreas to release more and more insulin, to produce the phenomenon of hyperinsulinism and the associated formation of grade II diabetes. If all the cells become resistant to insulin at the same time, there would be no problem. However, the cells acquire resistance at different speeds - first acquire resistance to liver cells, then the muscle tissue, and finally fat.
a. The resistance of liver cells
Insulin affects the liver in such a way that limits the amount of glucose produced by it. Sugar is present in the body comes from two sources - from what we eat and what the liver produces. In the morning, blood sugar is produced by the liver. If the organ is properly respond to insulin, it does not produce in the middle of the night too much glucose. However, if the liver becomes resistant to the effects of insulin, it begins to produce an excess of sugar in the morning, it appears having too much blood.
b. The resistance of muscle cells
Next, become resistant to insulin muscle tissue. Insulin enables glucose in the muscles burning inside their komórek.Jeśli muscle cells become resistant to it, can not burn that sugar in its interior. The liver still produces too much glucose, the muscles can not burn it down, thereby increasing blood sugar.
c. Resistance of adipose tissue
Fat cells also increase their resistance to insulin, but this occurs over a longer period of time. Insulin as we know it takes part in the deposition of fat in adipose tissue. As long as the fat cells do not 'resilience to the effects of insulin - tyjemy. At that time, the cells all the time increasing their resistance to the effects of insulin. In the end, the fat cells' resilience to its effects and then creates a reverse phenomenon - to lose weight, body fat. Increases continuously when the sugar concentration in the blood and the amount of insulin produced by pancreas. This is how diabetes.
d. Diseases of old age
Cells to insulin resistance is associated with the development of diseases of old age and is a major cause of aging in virtually all living creatures. Therefore, control of cell membrane resistance to insulin is extremely important.
5. Diabetes Treatment
You can cure a person suffering from diabetes but who still dominated by fluctuations of glucose in the blood, where hyperglycemia followed by hypoglycemia.
The ultimate goal of diabetes treatment should be to increase insulin sensitivity.
a. Control cell resistance to insulin through the use of EFA
The sensitivity of insulin cell membrane receptors can be reactivated but in most cases you can not restore their function to its original state. Insulin sensitivity can be increased through use of the right kind of nutrition, where the food contains enough essential fatty acids Omega-3, 6 and 9 and / or their supplements, because many people suffer from their large deficit. However, if you eat a diet excessive amount of unsaturated fatty acids, it becomes highly susceptible to oxidation. Therefore, one must also take vitamin E protects fats and eat unsaturated mono-and that is the olive oil. However, their excess in the body may endanger the health thanks to the existence of the phenomenon of oxidation.
Enhances insulin sensitivity in muscle training, so taking exercise is for all the most desirable.
b. Adjustment of cells to insulin resistance through the use of chromium
Very important in the sensitization of cells to insulin meets chromium, which is involved in active transport of insulin and glucose into the cell. Depending on the stage as I have in the body, diabetes must take daily 200 - 600 mcg of chromium chelated. Less is also important that the concentration of glucose in the blood, but what is the content of insulin in the blood because it reflects the degree of sensitivity to her body's cells. The use of additional appropriate amount of micronutrients such as zinc, selenium, manganese, vanadium, germany, copper, should aim at restoring high-efficiency combustion of fat. Elimination habit of burning the sugar will stabilize blood sugar levels even in people who are still resistant to insulin.
c. Action of vanadium sulphate (Vanadylu)
Vanadium sulfate mimics the effects of insulin. Its function in the body like insulin. However, it Wykorzystująe another mechanism for reducing blood sugar levels insulin sparing, thus helping to increase its sensitivity to cell membranes. In patients in whom insulin levels are too high to be applied in the first place, appropriate doses of chromium and is expected to decline in blood glucose concentration to a value of 95mg /%. In the absence of the effect of the chromium is in its place introduce Vanadyl slowly starting dose of 25 mgdobę, after a few days and then 50mg/dobę 75mg/dobę. Note - please do not treat yourself with hyperinsulinism on your own and that should take care of an experienced physician.
6. Vitamin C, sugar and insulin
Vitamin C is produced in almost all living mammals except humans. It is produced directly from glucose and in fact it has a similar structure. Since both these compounds have similar chemical structure, is competing with each other for access to the interior of cells. Receptor, allowing them to penetrate into the interior of cells in both cases is the same. The more sugar glucose to penetrate into cells, the smaller will be the interior of vitamin C.
Sugar weakens the immune system, because the body uses digestive internal resources of a large vitamin and mineral compounds. Vitamin C is needed white blood cells so that immune system cells - phagocytes can engulf factors wywołujęce infection in the body. White blood cells (leukocytes) have a much higher concentration of vitamin C on the inside than outside, so they have to store it. The concentration of glucose in the blood of 120 mg /% reduced phagocyte response by about 75%. Hyperinsulinism resulting in a lack of vitamin C in the cells can significantly impair the function of the immune system in protecting the body against agents infect and against cardiovascular disease and degenerative diseases regarded as.
7. Effect of insulin on the economy of magnesium
One of the many functions of insulin is the storage of magnesium in the cells. The body can not store it if the cells become resistant to insulin, and freed from their wnęterza is excreted in the urine.
The main function of magnesium is the production of energy, muscle relaxation and improve mental function. When is excreted outside, the blood vessels to constrict, increasing blood pressure and decreases the amount of energy produced. When increasing levels of insulin, the body loses calcium, magnesium, and the cells become more resistant to insulin. When blood vessels to shrink, glucose or insulin can not get inside cells - increases their resistance to insulin.
The increase in insulin promotes sodium retention in body fluids, causing fluid retention. As a result, we have high blood pressure and edema, or cardiac overload.
8. Hyperinsulinism cause of osteoporosis
The primary reason for the appearance of osteoporosis in a mass scale may be hyperinsulinism. Academic medicine assumes that calcium should always get to the bone, but in fact it is not. When the high concentration of insulin enjoy the calcium, the majority of this element is excreted in the urine and this has no influence on the inhibition of progress of osteoporosis.
Some calcium intake should be settled in the bones, but unfortunately hiperinsulinizmie too slowly. Some calcium can settle in my bones, but his whole weight goes to the arteries, which are slowly calcifying.
9. Effect of insulin on the cardiovascular system
The immediate effect of eating high-carbohydrate meal is to raise blood sugar levels, causing an increase in insulin levels, and this in turn results in contraction of the arteries. May occur if the symptoms of myocardial ischemia. Excess insulin in the blood affects the synthesis of nitric oxide, reducing its production in the endothelium. This in turn controls the expansion and contraction of blood vessels.
10. Effect of hyperinsulinism on the coagulation system
Excess insulin in the blood accelerates coagulation. This causes the conversion of macrophages in the spongy cells, which accumulate fat stores. Initiates the deposition of atherosclerotic plaques in blood vessels, narrowing the arteries, increases the viscosity of blood platelets, and the tendency to blood clotting in the vessels.
11. Effect of insulin on thyroid function
Under the influence of pituitary hormone TSH thyroid gland produces the hormone thyroxine (T4). This hormone is transported to the liver and there converted to triiodothyronine (T3). Insulin controls the majority of processes in the liver and is the first body, which becomes resistant to it. With the growth of the resistance of the body cells of the organ ceases to properly synthesize the hormones T3 from T4. Quite often, people with diabetes chorujący have the correct level of pituitary hormone TSH, high T4 but low levels of T3.
12. Protein glycation
Everyone knows that the oxidation process causes multiple damage in the body. Similar to the oxidation phenomenon is glycation, which is based on a combination of glucose from protein, leading to the destruction of its structure. White blood cells are catching damaged proteins and remove them from the body but not all, damaged proteins can be removed. Proteins undergo glycation does not regenerate easily and example of this is the collagen or protein myelin sheaths of nerves. These proteins the body can not get rid of, so they are aggregated, and with them products of its disintegration. Damage to nawarstwiają. This is also the collagen builds arteries. When you connect to the macrophage protein degradation product formed at this point the body's inflammatory focus. Diseases of the cardiovascular system are also a kind of inflammatory process. An spożtywająca excess of carbohydrates, proteins zglikowanych produces more, and this gives rise to all kinds of inflammation. Inflammation is now something so common that academics try to convince doctors to their patients, so he must be, not knowing of course what is the cause.
13. The healing principles of nutrition in hiperinsulinizmie
It should be mandatory for all permanent nutrition policy - do not eat carbs and proteins without the fiber plant. I recommended food containing a small amount of carbohydrates and fiber are vegetables. I recommend to eat all the vegetables and the most valuable ingredients for our health include garlic and onion.
Fruits contain, unfortunately, too many simple sugars, so I recommend to consume in reasonable quantities. Valuable ingredients for our health include strawberries, blueberries and blueberries.
Protein in addition to carbohydrates and fats is an essential nutrient. You have to use it as a building material, because the body needs protein for tissue repair and production of enzymes. I think that should not be treated as the main protein source of energy because it is raising its inefficient. You can calculate the amount of protein per day, which is essential to a person in relation to energy expenditure and due weight. Should eat throughout the day about 1 - 2g protein per kilogram of body weight. You should not consume less of it in the long run because this will contribute to a significant decrease in body weight and this is not a beneficial, because then your body will consume its own body tissues.
High protein diet is acidifying effect the body and fruit and vegetables have alkalizing properties. Should eat protein, eat them with vegetables. I do not recommend high protein diet but with a proper proportion of fat relative to protein.
I believe that people using so far should be used wysokowęglowodanową diet fat as an alternative energy source compared to carbohydrates. In total, over 50% of calories should come from unsaturated fats - olive oil and cold stamping, linseed oil and grapeseed oil. The diet should be low in saturated fat animal.
We do have stocks of saturated fat that most of us just go for a long period of time. I propose that the meals contain about 20% of calories from carbohydrates, 25 - 30% from protein and 60 - 65% from fat. This is the meat and vegetable diet, which uses an average of lean meat, but the pig is inserted above the right amount of oils - 5 or 6 tablespoons. Fish should consume about four times a week, preferably sardines.
Everyone should at some time to control insulin levels, which in Poland is difficult to implement.
